Minimizing reference bias with an imputed personalized reference
Published in Genome Research, 2026
The impute-first framework builds a personalized reference through imputation before aligning the full read set, reducing reference bias in downstream variant calling.
My contribution includes a linear-reference workflow using LevioSAM2 to lift personalized alignments to a standard reference.
Recommended citation: Vaddadi, Kavya, Mao-Jan Lin, Sina Majidian, Taher Mun, and Ben Langmead. "Minimizing reference bias with an imputed personalized reference." Genome Research (2026).
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